ASTM-E1811:2001 Edition

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E1811-96(2001) Standard Test Method for Oncogenicity Study in Rats and Mice

Published By	Publication Date	Number of Pages
ASTM	2001	4

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Category: ASTM

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Description

ASTM E1811-96-Reapproved2001

Historical Standard: Standard Test Method for Oncogenicity Study in Rats and Mice

ASTM E1811

Scope

1.1 This test method covers a long-term study to determine the oncogenicity potential of a substance in mammalian species such as the rat and mouse. the objective is to observe the test animals for a major portion of their life span for neoplastic lesions during exposure to various doses of a test substance by oral administration.

1.2 This test may also provide some information on long-term general toxicity.

1.3 This test method assumes that the user is knowledgeable in mammalian toxicology and related pertinent areas, and it relies heavily on the judgment of the evaluator.

1.4 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only.

1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. Specific hazards statements are given in Section 6.

Keywords

chronic toxity; feed efficiency; gavage hematology; mice; necropsy; ongenicity; oral; pesticide; rat; toxicity; tumor

ICS Code

ICS Number Code 11.100 (Laboratory medicine)

DOI: 10.1520/E1811-96R01

PDF Catalog

PDF Pages	PDF Title
1	Scope Referenced Documents Terminology
2	Significance and Use Hazards Facilities Test Animals Diets Procedure
3	Interpretation of Results
4	Report Quality Assurance Precision and Bias Keywords